[Inflammatory myofibroblastic tumor of the larynx: a case report]

Inflammatory myofibroblatic tumor is a recently caracterized solid mesenchymal tumor. They are frequently localised in the lung. However, the head and neck forms are uncommon. To report a new case of inflammatory myofibroblastic tumor of the larynx. This 47-year old man presented with dysphonia without dyspnea. Laryngoscopy showed a tumor of anterior vocal cord. CT scan of larynx confirmed diagnosis. The patient had a cordectomy. Histology concluded to the diagnosis of inflammatory myofibroblastic tumor. No relapses have been noted after 4 months. Only a few cases of laryngeal inflammatory myofibroblastic tumor have been reported in the literature. Clinical presentation depends of tumor location. Radiological images are not specific and diagnosis is based on histology. The expected course is essentially marked by the risk of local recurrences. Surgical excision seems to be the treatment of choice

The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding / 亚洲男科学杂志(英文版)

<p><b>AIM</b>to investigate the effects of crude garlic on adult male rat reproductive functions.</p><p><b>METHODS</b>Thirty male rats were divided into five groups: group 1 (untreated) and groups 2, 3, 4 and 5 were fed for 30 days with 5%, 10%, 15% and 30% crude garlic, respectively. Testes and accessory organs were weighed and some markers were assessed. Light and electron microscopy observations were also performed.</p><p><b>RESULTS</b>A significant decrease was observed in the body weight of groups 4 (14%; P < 0.01) and 5 (20%; P < 0.01); of the prostate weight in group 5 (29.1%; P < 0.05) and of seminal vesicle weight in groups 3 (14.4%; P < 0.01), 4 (18.3%; P < 0.01) and 5 (27.3%; P < 0.01). In contrast, testis and epididymis weights were unchanged. In epididymis tissue, the alpha glucosidase activity and the spermatozoa density were unchanged. The treatment resulted in a significant decrease in testosterone serum levels in groups 3 (77.3%; P < 0.01), 4 (77.3%; P < 0.01) and 5 (90.9%; P < 0.01), associated with a significant increase in LH serum levels (P < 0.01). Testicular histology showed a dose-dependent increase in the percentage of empty seminiferous tubules. Moreover, testicular function was affected; a significant decrease in phosphatase acid activity (P < 0.01) and testosterone (P < 0.05) contents were observed.</p><p><b>CONCLUSION</b>Crude garlic consumption during 1 month reduced testosterone secretion and altered spermatogenesis at 10%, 15% and 30% doses.</p>

[Diagnostic contribution of HBME- 1 and anti -cytokeratin-19 antibodies in thyroid pathology: a retrospective study of 163 cases]

To estimate the expression of 2 antibodies HBME-l and anti-cytokeratin-19 and their diagnostic importance in thyroid pathology.163 thyroid lesions were retrospectively examined by immnohistochemistry. 92% [46/50 cases] of papillary carcinomas expressed HBME-l as well as 50% [8/16 cases] of follicular carcinomas and 15% [6/40 cases] of follicular adenomas. 8 insular carcinomas, 5 anaplastic carcinomas, 20 cases of Basedow disease and lymphocytic thyroiditis, and the 24 cases of nodular goiters did not express it or very focally. Cytokeratine-19 marked 92% of papillary carcinomas, 56.2% of follicular carcinomas, 100% of the medullar carcinomas and 45% of follicular adenomas. Whereas the cases of anaplastic carcinomas, Basedow disease, thyroiditis and the cases of nodular goiters were negative or focally marked. HBME-1 is an excellent marker for papillary carcinoma which can be helpful in the diagnosis of its follicular variant the association with anti-cytok‚ratine-19 increases its specificity

Seric neuron specific enolase in pediatric neuroblastoma. Retrospective results about 21 patients

To report the results of seric neuron specific enolase in pediatric neuroblastoma. Our retrospective study concerns 21 children treated in our institution from 1992 to 1998 for neuroblastoma. Seric NSE was determined by immunoenzymology technique at different stages of the disease and the treatment Mean value for the 39 dosages of the whole patients was 127.9 ng/ml with a sensitivity of 56 percent five patients has presented normal values. Mean value for the 18 patients in stage IV was 132.38 ng/ml. we also observed in 3 patients, an evolution of the seric NSE parallel to this of the disease under chemotherapy. NSE represents a moderate sensitive and specific tumor marker for pediatric neuroblastoma. However, it represents a good value in prognosis and follow-up after chemotherapy